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Thiruma Arumugam

Neuroscientist, La Trobe University (Melbourne)
ScienceWorld
LongevityNutrition
Last updated: 7 October 2026

At a glance

  • Professor at the School of Agriculture, Biomedicine and Environment, La Trobe University in Melbourne; previously worked in Singapore and South Korea.
  • Studies how intermittent fasting and meal timing protect the brain against ageing, stroke and dementia.
  • Co-authored with Mark Mattson the widely cited review ‘Hallmarks of Brain Aging’ (Cell Metabolism, 2018), on the processes that make the brain more vulnerable with age.
  • Recent animal studies show that intermittent fasting reshapes the brain’s protein profile and protects synapses, and that liver, brain and muscle each respond to fasting in their own way.
  • Has also examined whether parents’ time-restricted feeding affects their offspring’s metabolism, and works on vascular dementia.
  • Relevant because fasting is often promoted with big promises for the brain; his work shows which biological mechanisms may lie behind it.

Criticism and nuance

Much of the research is done in mice; how large the effects of fasting are on the human brain remains uncertain.

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