Engy › Who's who in longevity › Alexey Moskalev
At a glance
- Russian ageing biologist at the Institute of Biology of Aging and Healthy Longevity, part of the Petrovsky National Research Centre of Surgery in Moscow.
- One of the best-known names around ‘geroprotectors’: substances, from drugs to food compounds, that might slow ageing processes.
- Co-founder of Geroprotectors.org, a public database tracking which substances extended lifespan, and in which organisms.
- Works extensively with fruit flies to study the genetics of lifespan, and on biomarkers of ageing, including blood protein measurements.
- Recent reviews cover dietary compounds and ‘inflammaging’ (chronic low-grade inflammation with age), and the effects of constant light exposure and melatonin deficiency.
- Relevant because he maps much of the scientific landscape of anti-ageing substances; useful for seeing what has already been tested — and in which organism.
Criticism and nuance
Much of the research on geroprotectors is done in fruit flies, worms or rodents; for most substances, evidence in humans is lacking.
Recent
- Study Aptamer-Based Platforms for Human Aging Biomarkers: Multiplexed Proteomics, Biosensors and Translational Perspectives
- Study Age-dependent physiological responses and longevity in three Drosophila species with contrasting lifespans exposed to low temperature and constant darkness
- Study Continuous Light Exposure as Factor in Pro-Senescent Liver Remodeling: Key Role of Melatonin Deficiency
- Study Dietary bioactive compounds and inflammaging: Pro-inflammatory triggers and geroprotective countermeasures
- Study Natural modulators of enhancer of zeste homolog 2 (EZH2): potential epigenetic regulators of aging-associated pathways